Document Abstract
Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, represents a global
health challenge with increasing prevalence. While the classic understanding of diabetes primarily
revolves around insulin resistance and impaired beta-cell function, emerging evidence highlights the
pivotal role of inflammation in its pathogenesis. This abstract provides an overview of the intricate
interplay between inflammatory processes and the development and progression of diabetes.The
role of inflammatory pathways extends beyond insulin resistance, influencing the onset of type 1
diabetes as well. Autoimmune destruction of pancreatic beta-cells involves the activation of
inflammatory responses orchestrated by T cells and other immune effectors. Understanding these
molecular and cellular processes opens avenues for novel therapeutic interventions targeting
inflammation to modify the course of diabetes. In conclusion, this abstract highlights the
multifaceted role of inflammation in the pathogenesis of diabetes, encompassing both type 1 and
type 2 diabetes. Targeting inflammatory pathways presents a promising approach for the
development of novel therapeutic strategies, emphasizing the need for a comprehensive
understanding of the immune-metabolic interplay in diabetesmellitus.